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Discovery of Genetic Alterations in Early-Onset Breast Cancer: A Study of Patients Aged 35 or Younger

Yale R. Kwon
 Thomas Jefferson High School for Science and Technology, Alexandria, VA, USA 
​Publication date: February 11, 2025
​DOI: http://doi.org/10.34614/JIYRC202442
ABSTRACT 
Breast cancer in women under 35 years old tends to be more aggressive, with poorer survival outcomes compared to older patients. This study investigates genetic alterations associated with early-onset breast cancer to identify potential biomarkers for the disease’s severity in younger patients. Using the cBioPortal database, we analyzed genomic data from breast cancer patients aged ≤35, 35-75, and >75 to examine gene amplification, deletion, and mutation patterns. Functional predictions were performed using GeneMANIA. Our findings reveal key genetic differences, including COX5A mutations, ABCA gene family amplifications, and significant gene deletions on chromosomes 7p15.3 and 21q22.3, which may contribute to the aggressive nature of breast cancer in younger patients. These results highlight critical genomic regions and pathways that could serve as targets for early diagnosis and therapeutic interventions.

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