A Systematic Review of Selective Serotonin Reuptake Inhibitors and Serotonin and Norepinephrine Reuptake Inhibitors
Hanbi Gim
Tessellations School, Los Altos, CA, United States
Publication date: November 20, 2025
Tessellations School, Los Altos, CA, United States
Publication date: November 20, 2025
DOI: http://doi.org/10.34614/JIYRC2025II61
ABSTRACT
Anxiety and depression are the result of neurological complications in the human brain. More specifically, both are the result of neurotransmitters and other chemicals working in a detrimental manner. Serotonin and other neurotransmitters are reabsorbed by presynaptic neurons, which in turn leads to a situation where the brain does not receive the optimal dosage of the chemicals. As such, contemporary medicine focuses on inhibiting the reabsorption of the chemicals by the presynaptic neuron. Such medications are known as antidepressants, and includes selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), both of which focus on blocking the reuptake process from happening in the presynaptic neuron. This review manuscript strives to summarize the main drug variants within the two subgroups and thus explain the different characteristics of each variation.
Anxiety and depression are the result of neurological complications in the human brain. More specifically, both are the result of neurotransmitters and other chemicals working in a detrimental manner. Serotonin and other neurotransmitters are reabsorbed by presynaptic neurons, which in turn leads to a situation where the brain does not receive the optimal dosage of the chemicals. As such, contemporary medicine focuses on inhibiting the reabsorption of the chemicals by the presynaptic neuron. Such medications are known as antidepressants, and includes selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), both of which focus on blocking the reuptake process from happening in the presynaptic neuron. This review manuscript strives to summarize the main drug variants within the two subgroups and thus explain the different characteristics of each variation.
