Targeting Exercise-Induced Epigenetic Changes as Therapy for Neurodegenerative Disorders
Juwon Hwang
Cardigan Mountain School, Canaan, United States
Publication date: May 31, 2025
Cardigan Mountain School, Canaan, United States
Publication date: May 31, 2025
DOI: http://doi.org/10.34614/JIYRC2025I06
ABSTRACT
Exercise induces various changes in the brain that significantly impact cognitive functions and stress management. While the physical benefits of exercise are well-established, recent research highlights its intricate connections to other cognitive pathways involving memory, language skills, and attention through epigenetic modifications. These changes, including DNA methylation and histone modification, improve synaptic plasticity and enhance cognitive performance. Furthermore, exercise is linked to better stress management by regulating key molecular pathways. Despite these promising findings, our understanding of the precise mechanisms through which exercise exerts its effects remains incomplete. This paper suggests that incorporating exercise into therapeutic strategies offers a novel and effective approach to enhancing cognitive function and managing stress, particularly in patients with neurodegenerative disorders. By exploring the molecular basis of exercise-induced changes, future research should focus on developing personalized exercise programs to maximize these benefits. Ultimately, integrating exercise with conventional therapies could provide a comprehensive treatment strategy, improving the quality of life for individuals with cognitive impairments.
Exercise induces various changes in the brain that significantly impact cognitive functions and stress management. While the physical benefits of exercise are well-established, recent research highlights its intricate connections to other cognitive pathways involving memory, language skills, and attention through epigenetic modifications. These changes, including DNA methylation and histone modification, improve synaptic plasticity and enhance cognitive performance. Furthermore, exercise is linked to better stress management by regulating key molecular pathways. Despite these promising findings, our understanding of the precise mechanisms through which exercise exerts its effects remains incomplete. This paper suggests that incorporating exercise into therapeutic strategies offers a novel and effective approach to enhancing cognitive function and managing stress, particularly in patients with neurodegenerative disorders. By exploring the molecular basis of exercise-induced changes, future research should focus on developing personalized exercise programs to maximize these benefits. Ultimately, integrating exercise with conventional therapies could provide a comprehensive treatment strategy, improving the quality of life for individuals with cognitive impairments.
