Development and Analysis of Low-Frequency Ultrasound Wave Therapy on 2D and 3D-Cultured Brain and Breast Cancer Cells
Junseo Yu
North London Collegiate School, Jeju, Korea
Publication date: May 31, 2025
North London Collegiate School, Jeju, Korea
Publication date: May 31, 2025
DOI: http://doi.org/10.34614/JIYRC2025I03
ABSTRACT
This study investigates the comparative efficacy of sound wave therapy on two human cancer cell types: A172 brain cancer cells and MCF7 breast cancer cells. Sound wave therapy is known for its targeted cytotoxic effects on certain cancer cells; however, its potential impact on brain cancer cells is less explored. Using a 20,000 Hz frequency sound wave generator in a controlled incubator setup, we assessed cellular viability, morphological changes, and cell confluency under varied sound wave exposure. Results demonstrated that sound wave treatment induced a significant reduction in MCF7 breast cancer cell viability, showing a promising effect on breast cancer cytotoxicity. In contrast, A172 brain cancer cells showed limited response to the treatment under identical conditions, suggesting a differential susceptibility to sound wave therapy. This study provides initial insights into sound wave therapy’s selective efficacy, encouraging further investigation into optimizing frequency and treatment conditions to maximize therapeutic outcomes for specific cancer types.
This study investigates the comparative efficacy of sound wave therapy on two human cancer cell types: A172 brain cancer cells and MCF7 breast cancer cells. Sound wave therapy is known for its targeted cytotoxic effects on certain cancer cells; however, its potential impact on brain cancer cells is less explored. Using a 20,000 Hz frequency sound wave generator in a controlled incubator setup, we assessed cellular viability, morphological changes, and cell confluency under varied sound wave exposure. Results demonstrated that sound wave treatment induced a significant reduction in MCF7 breast cancer cell viability, showing a promising effect on breast cancer cytotoxicity. In contrast, A172 brain cancer cells showed limited response to the treatment under identical conditions, suggesting a differential susceptibility to sound wave therapy. This study provides initial insights into sound wave therapy’s selective efficacy, encouraging further investigation into optimizing frequency and treatment conditions to maximize therapeutic outcomes for specific cancer types.
