Investigating the Genetic Overlap Between Bipolar Disorder and Major Depressive Disorder: The Role of the MTSS1L Gen
C. Park
Dulwich College Seoul, Seoul, South Korea
Publication date: November 4, 2024
Dulwich College Seoul, Seoul, South Korea
Publication date: November 4, 2024
DOI: http://doi.org/10.34614/JIYRC202420
ABSTRACT
Bipolar affective disorder (BPAD) and major depressive disorder (MDD) are complex psychiatric conditions with shared depressive symptoms. However, the genetic linkage of these two conditions is poorly investigated. Therefore, this study examines the genetic overlap between BPAD and MDD, focusing specifically on the role of the MTSS1L gene. Moreover, the role of MTSS1L on cytoskeletal dynamics and its influence on depression-associated genes was investigated. The result showed that siRNA-dependent inhibition of MTSS1L expression in human glial cells led to a more elongated morphology, commonly observed when the cytoskeletal dynamics malfunction. In addition, the downregulation of MTSS1L led to increased expression of BDNF and SLC6A4, indicating a potential inverse relationship between MTSS1L activity and depression-related gene expression. Overall, this study highlights a novel genetic connection between BPAD and MDD, providing insight into the shared biological pathways that may underlie both disorders.
Bipolar affective disorder (BPAD) and major depressive disorder (MDD) are complex psychiatric conditions with shared depressive symptoms. However, the genetic linkage of these two conditions is poorly investigated. Therefore, this study examines the genetic overlap between BPAD and MDD, focusing specifically on the role of the MTSS1L gene. Moreover, the role of MTSS1L on cytoskeletal dynamics and its influence on depression-associated genes was investigated. The result showed that siRNA-dependent inhibition of MTSS1L expression in human glial cells led to a more elongated morphology, commonly observed when the cytoskeletal dynamics malfunction. In addition, the downregulation of MTSS1L led to increased expression of BDNF and SLC6A4, indicating a potential inverse relationship between MTSS1L activity and depression-related gene expression. Overall, this study highlights a novel genetic connection between BPAD and MDD, providing insight into the shared biological pathways that may underlie both disorders.
