6-gingerol Protects Human Brain Cells in Alzheimer’s Disease Mode
Shue Park
Dubai American Academy, Dubai, United Arab Emirates
Publication date: September 19, 2024
Dubai American Academy, Dubai, United Arab Emirates
Publication date: September 19, 2024
DOI: http://doi.org/10.34614/JIYRC202408
ABSTRACT
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive neurodegenerative disorder that disproportionately affects the aging population. Despite numerous studies, no current treatment provides an optimal therapeutic effect for AD, highlighting the need to explore alternative approaches. Recently, 6-gingerol, a bioactive compound found in ginger, has garnered attention for its antioxidant and anti-inflammatory properties and potential protective effect against AD. Therefore, this research aimed to demonstrate the protective effect of 6-gingerol on two distinct human brain cells, A172 and SHSY5Y. The optimal concentration of gingerol ranged from 10 nM to 30 nM, as higher concentrations adversely affected cell viability. In this study, this gingerol concentration exhibited a clear protective effect on scopolamine hydrobromide-treated A127 cells, which mimic AD. When treated with gingerol, cell viability significantly increased without any side effects. This outcome was also observed in 3D cultured SHSY5Y cells, highlighting gingerol’s potential as a therapeutic agent in AD. This study underscores the promising role of 6-gingerol in treating and preventing AD, offering a potential approach for future therapeutic interventions in AD research.
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive neurodegenerative disorder that disproportionately affects the aging population. Despite numerous studies, no current treatment provides an optimal therapeutic effect for AD, highlighting the need to explore alternative approaches. Recently, 6-gingerol, a bioactive compound found in ginger, has garnered attention for its antioxidant and anti-inflammatory properties and potential protective effect against AD. Therefore, this research aimed to demonstrate the protective effect of 6-gingerol on two distinct human brain cells, A172 and SHSY5Y. The optimal concentration of gingerol ranged from 10 nM to 30 nM, as higher concentrations adversely affected cell viability. In this study, this gingerol concentration exhibited a clear protective effect on scopolamine hydrobromide-treated A127 cells, which mimic AD. When treated with gingerol, cell viability significantly increased without any side effects. This outcome was also observed in 3D cultured SHSY5Y cells, highlighting gingerol’s potential as a therapeutic agent in AD. This study underscores the promising role of 6-gingerol in treating and preventing AD, offering a potential approach for future therapeutic interventions in AD research.