Antibacterial Properties of DEFB1 Protein Against Oral Bacteria Streptococcus mutans
Sowon Bok
Saint Paul Preparatory Seoul, 50-11 Banpo-dong, Seocho-gu, Seoul, South Korea
Publication date: September 6, 2024
Saint Paul Preparatory Seoul, 50-11 Banpo-dong, Seocho-gu, Seoul, South Korea
Publication date: September 6, 2024
DOI: http://doi.org/10.34614/JIYRC202406
ABSTRACT
This study aims to investigate the role of the antimicrobial peptide DEFB1 in inhibiting dental caries. The previous research found that individuals with homozygous dominant TT genotypes (rs11362) in the DEFB1 gene showed higher dental cavities. Using the Genotype-Tissue Expression database, we found that individuals with TT genotype demonstrate lower DEFB1 levels. This result may indicate a correlation between reduced DEFB1 expression and increased susceptibility for caries. We further analyzed how DEFB1 concentrations affect the extension of Streptococcus mutans (S. mutans), a primary bacterium responsible for caries. The relationship between DEFB1 concentration and the growth of S. mutans revealed an inverse correlation. Additionally, incorporating DEFB1 into toothpaste demonstrated that the protein maintains its function of suppressing S. mutans under different environmental conditions. These insights showed that DEFB1’s role is valuable in dental health industries. Overall, this approach will enhance the usefulness of DEFB1 in preventing dental caries. Also, it could lead to more effective dental treatments for those genetically susceptible to caries.
This study aims to investigate the role of the antimicrobial peptide DEFB1 in inhibiting dental caries. The previous research found that individuals with homozygous dominant TT genotypes (rs11362) in the DEFB1 gene showed higher dental cavities. Using the Genotype-Tissue Expression database, we found that individuals with TT genotype demonstrate lower DEFB1 levels. This result may indicate a correlation between reduced DEFB1 expression and increased susceptibility for caries. We further analyzed how DEFB1 concentrations affect the extension of Streptococcus mutans (S. mutans), a primary bacterium responsible for caries. The relationship between DEFB1 concentration and the growth of S. mutans revealed an inverse correlation. Additionally, incorporating DEFB1 into toothpaste demonstrated that the protein maintains its function of suppressing S. mutans under different environmental conditions. These insights showed that DEFB1’s role is valuable in dental health industries. Overall, this approach will enhance the usefulness of DEFB1 in preventing dental caries. Also, it could lead to more effective dental treatments for those genetically susceptible to caries.
