Targeting CD44 in GBM: Chitosan Nanoparticles Induce Apoptosis
Y. Kang
Seoul Foreign School, Seoul, South Korea
Publication date: September 5, 2024
Seoul Foreign School, Seoul, South Korea
Publication date: September 5, 2024
DOI: http://doi.org/10.34614/JIYRC202405
ABSTRACT
Brain tumors can pose significant challenges due to their intricate nature and the limited space within the skull. Glioblastoma (GBM), an aggressive primary brain tumor, presents particularly daunting treatment hurdles despite therapy advances. Various factors hinder treatment, including their infiltration into the vital brain regions and the presence of the blood-brain barrier (BBB) limiting drug delivery. This study investigates the potential of chitosan nanoparticles (CNPs) in targeting CD44-abundant A172 GBM cells. Isolation of non-adherent and adherent cancer cells through cycles of cell culture, along with live cell imaging techniques to examine the disparity in cell morphology, reveals the impact of CNPs on cell viability. Our results indicate that CNPs induce apoptotic cell death in CD44- expressing cells, suggesting a therapeutic avenue for targeting brain cancer. Overall, CNPs hold promise as a selective and effective approach for enhancing the specificity and efficacy of cancer drug delivery.
Brain tumors can pose significant challenges due to their intricate nature and the limited space within the skull. Glioblastoma (GBM), an aggressive primary brain tumor, presents particularly daunting treatment hurdles despite therapy advances. Various factors hinder treatment, including their infiltration into the vital brain regions and the presence of the blood-brain barrier (BBB) limiting drug delivery. This study investigates the potential of chitosan nanoparticles (CNPs) in targeting CD44-abundant A172 GBM cells. Isolation of non-adherent and adherent cancer cells through cycles of cell culture, along with live cell imaging techniques to examine the disparity in cell morphology, reveals the impact of CNPs on cell viability. Our results indicate that CNPs induce apoptotic cell death in CD44- expressing cells, suggesting a therapeutic avenue for targeting brain cancer. Overall, CNPs hold promise as a selective and effective approach for enhancing the specificity and efficacy of cancer drug delivery.
