The Effectiveness of Mesenchymal Stem Cells as a Treatment for Osteogenesis Imperfecta: A Systematic Review
Lexie Wu
Hunter College High School, New York City, U.S.
Publication date: July 19, 2026
Hunter College High School, New York City, U.S.
Publication date: July 19, 2026
DOI: http://doi.org/10.34614/JIYRC2026I44
ABSTRACT
Osteogenesis imperfecta (OI) is a heritable genetic disease that affects type I collagen production, causing bones to be brittle and vulnerable to fracture. Current treatments that aim to reduce fracture rate are varyingly successful. Administration of mesenchymal stem cells (MSCs) could be a more effective treatment for OI because of their ability to differentiate and migrate. A systematic literature review was performed following the PRISMA guidelines based on published studies involving the administration of MSCs in oim mouse models as well as human patients by exploring and evaluating how they work and their effectiveness and practicality in increasing bones’ mechanical strength. Bone affected by OI treated with MSCs result in reduced fracture rates, increased bone mineral content, increased osteogenesis rates, and increased mechanical strength.
Osteogenesis imperfecta (OI) is a heritable genetic disease that affects type I collagen production, causing bones to be brittle and vulnerable to fracture. Current treatments that aim to reduce fracture rate are varyingly successful. Administration of mesenchymal stem cells (MSCs) could be a more effective treatment for OI because of their ability to differentiate and migrate. A systematic literature review was performed following the PRISMA guidelines based on published studies involving the administration of MSCs in oim mouse models as well as human patients by exploring and evaluating how they work and their effectiveness and practicality in increasing bones’ mechanical strength. Bone affected by OI treated with MSCs result in reduced fracture rates, increased bone mineral content, increased osteogenesis rates, and increased mechanical strength.
