Evaluating the Wound-Healing Potential of Saururus chinensis Leaf Extracts and Sauchinone in Human Dermal Fibroblasts Using an In Vitro Scratch Assay
Colin Kim Doh
Korea International School Jeju, Jeju, South Korea
Publication date: July 10, 2026
Korea International School Jeju, Jeju, South Korea
Publication date: July 10, 2026
DOI: http://doi.org/10.34614/JIYRC2026I33
ABSTRACT
Saururus chinensis, a medical plant rich in lignans such as sauchinone, is known to exhibit anti-inflammatory and antioxidant effects. However, its direct role in human skin wound healing has not been clearly discovered. In this research, I used an in vitro scratch assay to examine the effects of sauchinone and leaf extracts from Saururus chinensis on fibroblast migration. According to our findings, Saururus chinensis extract treatment significantly improved wound closure, with 100 µL showing the strongest recovery, while higher concentrations decreased healing ability due to cytotoxicity. Sauchinone by itself promoted fibroblast migration, and at 1.0 μM, the percentage of recovery increased significantly, but at higher doses, cell viability was compromised. These results imply that sauchinone is a major active compound in Saururus chinensis's wound-healing ability, possibly through anti-inflammatory and ROS-reducing mechanisms. All things considered, this study offers fresh proof that Saururus chinensis could be a useful natural remedy for improving skin repair.
Saururus chinensis, a medical plant rich in lignans such as sauchinone, is known to exhibit anti-inflammatory and antioxidant effects. However, its direct role in human skin wound healing has not been clearly discovered. In this research, I used an in vitro scratch assay to examine the effects of sauchinone and leaf extracts from Saururus chinensis on fibroblast migration. According to our findings, Saururus chinensis extract treatment significantly improved wound closure, with 100 µL showing the strongest recovery, while higher concentrations decreased healing ability due to cytotoxicity. Sauchinone by itself promoted fibroblast migration, and at 1.0 μM, the percentage of recovery increased significantly, but at higher doses, cell viability was compromised. These results imply that sauchinone is a major active compound in Saururus chinensis's wound-healing ability, possibly through anti-inflammatory and ROS-reducing mechanisms. All things considered, this study offers fresh proof that Saururus chinensis could be a useful natural remedy for improving skin repair.
