Developing Natural Wound Healing Agents from Jeju Tangerine Byproducts for Veterinary Care
Jaeyoon Lee
Chadwick International, Incheon, South Korea
Publication date: July 10, 2026
Chadwick International, Incheon, South Korea
Publication date: July 10, 2026
DOI: http://doi.org/10.34614/JIYRC2026I29
ABSTRACT
Jeju Island generates large amounts of citrus byproducts, creating disposal burdens while also providing a rich source of bioactive compounds with therapeutic potential. This study investigated whether fresh and fermented tangerine peel extracts could support skin wound healing and whether fermentation improved extract functionality. Jeju tangerine byproducts were processed into fresh and fermented extracts, and their chemical composition was analyzed using HPLC, total phenolic and flavonoid assays, DPPH, and FRAP. Wound-healing activity was evaluated in mouse skin cells (L929) using a scratch assay across multiple concentrations. Fermentation reduced glycoside flavonoids and increased the corresponding aglycones, accompanied by higher total phenolic content and antioxidant activity. In biological testing, low-dose fermented extract (1 μL) produced the strongest wound closure, whereas higher concentrations inhibited cell migration. These findings indicate that fermented citrus waste is a promising sustainable source of natural veterinary wound-healing agents.
Jeju Island generates large amounts of citrus byproducts, creating disposal burdens while also providing a rich source of bioactive compounds with therapeutic potential. This study investigated whether fresh and fermented tangerine peel extracts could support skin wound healing and whether fermentation improved extract functionality. Jeju tangerine byproducts were processed into fresh and fermented extracts, and their chemical composition was analyzed using HPLC, total phenolic and flavonoid assays, DPPH, and FRAP. Wound-healing activity was evaluated in mouse skin cells (L929) using a scratch assay across multiple concentrations. Fermentation reduced glycoside flavonoids and increased the corresponding aglycones, accompanied by higher total phenolic content and antioxidant activity. In biological testing, low-dose fermented extract (1 μL) produced the strongest wound closure, whereas higher concentrations inhibited cell migration. These findings indicate that fermented citrus waste is a promising sustainable source of natural veterinary wound-healing agents.
